Scientific Advisors
Marina Cerrone, MD
Marina Cerrone, MD
Marina Cerrone, MD, received her medical degree and cardiology fellowship from the University of Pavia, Italy where she trained under the mentorships of Drs. Peter J Schwartz and Silvia Priori, developing an interest in clinical and translational cardiovascular genetics. She then completed her postdoc under Dr. Jose Jalife at SUNY Upstate Medical University in Syracuse, NY and the University of Michigan, Ann Arbor where she worked in basic electrophysiology and in the characterization of mechanisms of inherited arrhythmias using genetically engineered mouse models.
In 2008 together with Dr. Silvia Priori she contributed to the development of the Inherited Arrhythmias Clinic at NYU Langone Health, and currently she is the Co-director of the clinic’s research component. She focuses her current clinical studies on genotype-phenotype correlations, new risk indicators, new gene discovery and clinical trials of patients with heritable arrhythmias.
Her translational research interests focus on understanding the basic mechanisms and modifiers that determine the risk of lethal arrhythmias and sudden death in the setting of inherited arrhythmias and cardiomyopathies, especially using engineered mouse models. She is currently working with a mouse model of Arrhythmogenic Cardiomyopathy (ARVC) studying the pleiotropic functions of desmosomal protein and their role in facilitating arrhythmias in ARVC. To learn more about her research, please visit Dr. Cerrone’s PubMed.
Allison Cirino, MS, CGC
Allison Cirino, MS, CGC
Allison Cirino, MS, CGC, is an Associate Professor at MGH Institute of Health Professions Genetic Counseling Program and a licensed genetic counselor in the Brigham and Women’s Hospital Cardiovascular Genetics Center where she has been involved in patient care, educational initiatives, and numerous cardiovascular genetics research projects since 2004. She currently serves on various committees for the National Society of Genetic Counselors (NSGC) and the American Heart Association (AHA). She is a Fellow of the AHA and serves as the NSGC Liaison to the AHA Genomics and Precision Medicine Council.
Lisa Dellefave-Castillo, MS, CGC
Lisa Dellefave-Castillo, MS, CGC
Lisa graduated from the University of Minnesota Graduate Program in Molecular, Cellular, Developmental Biology and Genetics with her Master’s Degree specialized in Genetic Counseling in 2001. She started as a genetic counselor in Neuromuscular disorders and cancer. She has been specializing in cardiovascular genetics since 2006 first at the University of Chicago and then since 2014 at Northwestern University. During her time at Northwestern University, she helped to build the cardiovascular genetics clinic at the Northwestern Medicine, Bluhm Cardiovascular Institute. Lisa clinically sees all types of inherited cardiovascular disease including cardiomyopathies, arrhythmias, aortopathies and sudden cardiac death. She is involved in all aspects of the genetic testing process including pre-test counseling, post-test discussing genetic testing results, and helping with family communication. She also has a strong research focus through the Northwestern University, Center for Genetic Medicine where she is involved in studies to identify new genes in cardiovascular disease through whole genome sequencing as well as genomic profiling of sudden cardiac death and development of cardiovascular education modules for cardiology physicians and health care professionals.
Amit V. Khera, MD, MSc
Amit V. Khera, MD, MSc
Amit V. Khera, MD MSc, is a cardiologist, human geneticist, and population biologist. He is the Executive Director of Genomic Medicine at Verve Therapeutics and an Assistant Professor (on-leave) at Harvard Medical School.
He received his MD with Alpha Omega Alpha distinction from the University of Pennsylvania and went on to complete clinical training in Internal Medicine and cardiology at Brigham and Women’s Hospital and MGH.
His research program used genetic variation as a tool to uncover new biology and enable enhanced clinical care informed by inherited susceptibility. Among his scientific contributions, he pioneered use of a new approach to quantify genetic risk (‘genome-wide polygenic scores’) for common diseases, developed biomarkers that provide new biologic insights, and analyzed large-scale gene sequencing data to highlight key pathways driving risk and identify molecular subtypes of cardiometabolic diseases.
Dr. Khera has authored more than 100 scientific publications, including lead or senior-authored publications in the New England Journal of Medicine, Journal of the American Medical Association, Cell, and Nature Genetics.
In tandem with his research efforts, he founded a Preventive Genomics Clinic at MGH to provide a clinical infrastructure for genome-first medicine.
Joshua Knowles, PhD
Joshua Knowles, PhD
Dr. Joshua Knowles is a physician-scientist whose career path has centered around the genetic basis of cardiovascular disease with contributions across the continuum from Discovery to the development of Model Systems to the Translation of these findings to the clinic and most recently to the Public Health aspect of genetics. Currently, his Discovery and basic translational efforts center on understanding the genetic basis of insulin resistance using GWAS studies coupled with exploration in model systems including standard cell lines, induced pluripotent stem cells and murine models. These efforts are funded through the NIH, AHA and ADA. His clinical translational focus is on the intersection of lipids and insulin resistance, particularly defining how statins increase the risk of diabetes (Doris Duke Foundation). His clinical role at Stanford is as a lipidologist and director of the Familial Hypercholesterolemia (FH) clinic, which provides world-class care to individuals with FH and related lipid disorders. His interest in FH has led me to explore innovative ways of addressing the major public health impact of this genetic condition. As the volunteer Chief Medical Advisor of the FH Foundation (a patient-led research and advocacy organization), Dr. Knowles led the FH Foundation’s efforts to establish a national patient registry for FH (CASCADE FH) and apply for an ICD10 code for FH. He has used cutting-edge “big-data” approaches to identify previously undiagnosed FH patients in electronic medical records (the FIND FH project, partly funded by the AHA).
Alejandra Guerchicoff, PhD
Alejandra Guerchicoff, PhD
Dr. Alejandra Guerchicoff, Ph.D., has dedicated her professional career to improving the quality of life of people with heart disease through basic & clinical research and education. Dr. Guerchicoff has studied for more than 20 years genomics and genotype-phenotype relationships in heritable cardiovascular diseases. Her work includes novel genetic changes identification related to the cardiac channelopathies, catecholaminergic polymorphic ventricular tachycardia and sudden death, and inherited sarcomere diseases.
Dr. Guerchicoff served for 16 years as Director of the Genetics of Cardiac Arrhythmias Laboratory at the Masonic Medical Research Laboratory as well as the Genetic Testing Laboratory for the Cardiogenomic NYU University. Under her leadership the laboratories have helped a countless number of patients and family members through the genetic testing and by providing consulting services to patients, families, academic institutions, physicians, health insurance providers and genetic counselors.
In addition, as Scientific Director of Cardiogenomica Argentina Dr. Guerchicoff has active genetic counselor and gene analysis efforts devoted to identifying, through genetic testing, individuals and families at greatest risk of heritable cardiovascular diseases.
Marianna Guerchicoff, MD
Marianna Guerchicoff, MD
Dr. Marianna Guerchicoff, M.D., is the Head of Pediatric Arrhythmia and Electrophysiology Unit of the Italian Hospital in Buenos Aires, Argentina, position that she holds for 21 years. She also serves a Medical Director of Cardiogenomics Argentina. In addition, Dr. Guerchicoff she serves as the voice and represents the Sudden Arrhythmia Death Syndromes (SADS) Foundation since 2009.
Dr. Guerchicoff endeavors to fulfill the two-fold objective of medical care and genetic testing and research. She specializes in genetic cardiology and takes care of patients and families at risk of sudden cardiac death from a variety of genetic heart diseases like cardiac channelopathies such as long and short QT syndrome, catecholaminergic polymorphic ventricular tachycardia and sudden unexplained death, including sudden infant death syndrome (SIDS), and inherited sarcomere diseases such as hypertrophic cardiomyopathy.
Dr. Guerchicoff and her team together, are working on improving the diagnostic, prognostic, and therapeutic approaches to these diseases through genetic testing, and enabling true individualized medicine for patients and families with genetic heart rhythm and genetic heart muscle diseases.
Siddharth Prakash, MD, PhD
Siddharth Prakash, MD, PhD
Siddharth Prakash has a Ph.D. in Molecular and Human Genetics from Baylor College of Medicine, where he also completed his residency in Internal Medicine and a fellowship in Cardiovascular Disease. Since 2011, Dr. Prakash has worked in the John Ritter Research Program in Aortic and Vascular Diseases at McGovern Medical School, a part of the University of Texas Health Science Center at Houston (UTHealth), where he specializes in medical therapy, imaging and surveillance of patients with heritable aortic and vascular diseases. He is Associate Professor of Internal Medicine and is co-director of the Turner Syndrome Adult Comprehensive Care Center. Dr. Prakash’s translational research l focuses on the contribution of rare genomic copy number variants (CNVs) to bicuspid aortic valve (BAV), the most common adult congenital heart defect. Dr. Prakash uses an innovative strategy to identify new candidate genes for BAV, based in part on the hypothesis that reduced dosage of genes on the X chromosome is responsible for the increased prevalence of BAV in males and in women with Turner syndrome. He identified recurrent CNVs in diverse clinical cohorts with BAV and demonstrated that specific rare CNVs are an important contributing cause of thoracic aortic aneurysms. Dr. Prakash received funding from the American Heart Association and National Institutes of Health follow up on these observations in patients with early complications of bicuspid aortic valve disease.
Ryan Rodarmer, MS
Ryan Rodarmer, MS
Ryan Rodarmer, MS, is an experienced cardiovascular genetic counselor with a diverse background in the field. For over 16 years, he served as the lead cardiac counselor at Spectrum Health, where he also provided comprehensive genetic counseling services across oncology and pediatrics. Currently, Ryan holds the position of Director of The VEDS Movement at The Marfan Foundation, focusing on support, education, and research initiatives for VEDS patients. Ryan also contributed as the Project Manager for the Genetic Testing Task Force at The SADS Foundation, where he worked to increase awareness and understanding of cardiogenomic testing among various stakeholders. As a type A aortic dissection survivor due to hereditary thoracic aortic disease, Ryan is passionate about advocating for genetic testing in cardiology and supporting patients with hereditary cardiac conditions.
Wai Hong Wilson Tang, MD
Wai Hong Wilson Tang, MD
Dr. Wai Hong Wilson Tang, M.D. is Professor of Medicine at Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. Dr. Tang is a heart failure/transplant cardiologist that specialized in cardiomyopathies (especially in inherited cardiomyopathies), cardio-renal diseases, and cancer-related heart diseases. Dr. Tang has previously served as the Director of the Center for Clinical Genomics at the Cleveland Clinic, and currently as the Medical Director for the Cleveland Clinic GeneBank Study. Dr. Tang has published over 750 peer-reviewed scientific manuscripts and 88 book chapters (h-index 97). He was elected as member of the American Society of Clinical Investigation in 2013 for his contributions to physiologic and mechanistic understanding of cardio-renal syndromes, as well as the Association of American Physicians in 2018 for studying the contributing role of diet and microbiome in cardiovascular diseases. He was also the recipient of the American College of Cardiology’s 2022 Distinguished Scientist Award in the Basic Domain.
Kate Orland, MS, CGC
Kate Orland, MS, CGC
Kate Orland, MS, CGC, licensed genetic counselor, has been the primary cardiac genetic counselor at the University of Wisconsin Cardiac Genetics Clinic since 2009. Kate sees both pediatric and adult patients for indications related to inherited arrhythmia, cardiomyopathy, and lipid disease, provides clinical supervision to genetic counseling graduate students and serves as a lecturer in both the UW GC program as well as the cardiology fellowship training program. Kate also supports research efforts focused on inherited cardiac disease at UW-Madison.
Olivia Roy, MS, CGC
Olivia Roy, MS, CGC
Olivia Roy, MS, CGC is a genetic counselor with the Texas Center for Pediatric and Congenital Heart Disease, a clinical partnership between Dell Children’s Medical Center and UT Health Austin. Currently, Olivia is working to build the cardiogenetic outpatient clinic for Dell Children’s Hospital in Austin. Her clinical interests include the genetic causes of congenital heart disease and any genomic-based managements that can be utilized in patient care. Olivia Roy earned a bachelor’s degree in biology from the University of San Diego and a Master of Science degree in Human Genetics and Genetic Counseling from Keck Graduate Institute.
Carly Scarborough, MS, CGC
Carly Scarborough, MS, CGC
Carly Scarborough, MS, CGC, is a cardiac genetic counselor at Levine Children’s Congenital Heart Center. She is the primary cardiac genetic counselor and both sees pediatrics and adults in the outpatient and inpatient settings. She is also the genetic counselor for the Marfan Syndrome and Aortopathy clinic in Charlotte and Hickory, NC clinics. Carly graduated with her Master of Science degree in Genetic Counseling from Rutgers University.
Janda Jenkins, MS, CGC
Janda Jenkins, MS, CGC
Janda Jenkins, MS, CGC, is a Genetic Counselor at Children’s Mercy Kansas City and leads the only pediatric cardiovascular genetics program in the region. Janda supports general cardiology, arrhythmia and heart failure/transplant services and has decades of experience with cardiac genetic testing. Janda also provides education and cardiovascular genetics expertise to adult cardiology colleagues in the Kansas City metro area.
Daria Ma, MS, LCGC, MHDS
Daria Ma, MS, LCGC, MHDS
Daria Ma, MS, LCGC, MHDS has been helping healthcare providers and consumers by translating complex medical genetic information into practical tools for clinical management for over a decade. Daria is currently the cardiovascular genetic counselor at Smidt Heart Institute at Cedars Sinai Medical Center in Los Angeles, CA, where she provides genetic services to suspected heritable heart disease patients of all ages. She is also extensively involved in the clinical operation, education, and development of the Cardiogenetics Program. Daria currently serves as the co-chair of the Genomic Technologies Special Interest Group at National Society of Genetic Counselors (NSGC). Past roles within NSGC includes co-chair of Artificial Intelligence/Machine Learning subcommittee and member of the Business Case Workgroup of the Access and Service Delivery Committee. With her Master’s degree in Genetic Counselor from Sarah Lawrence College and Master’s Degree in Health Delivery Science from Cedars Sinai Medical Center, Daria is passionate about delivering cost-effective genomic care programs to healthcare systems and the public.
Daria grew up in Vancouver, Canada, and currently lives in Los Angeles, CA. When not traveling to places near and far, you can find her laughing at improv comedy at the Groundlings, enjoying a play at a small theater in Hollywood, or chilling at home with a good biography or mystery novel in hand.
Brendan Floyd, MD, PhD, MEd
Brendan Floyd, MD, PhD, MEd
Dr. Brendan Floyd is a physician-scientist whose career path covers the overlap between pediatric genetics, metabolism, and pediatric cardiovascular disease, with a particular interest in cardiomyopathies. He is driven to expand the understanding of the genetic basis of disease, to share this knowledge with patients and families, and to apply the concepts of precision medicine to improve the outcomes for pediatric cardiac conditions. His clinical translational focus is on the genetic basis of pediatric cardiac diseases, from congenital heart defects to arrhythmias to cardiomyopathies. His research work has been published in top-tier journals including Cellular Metabolism and Circulation: Genomic and Precision Medicine. Dr. Floyd’s clinical role at Stanford is as a pediatric cardiologist, managing children from infancy through early adulthood. He is a member of the Pediatric Inherited Cardiovascular Diseases program, which provides comprehensive, leading-edge support for patients and families with genetic cardiovascular diseases.
Ana Morales, MS, CGC
Ana Morales, MS, CGC
Ana Morales is an Associate Professor at Geisinger Health and 2019 President of the American Board of Genetic Counseling. As a nationally recognized expert on cardiomyopathy, Ana’s work has appeared in more than 60 peer-reviewed publications, including the 2010 seminal manuscript that for the first time showed that DCM gene variants can be found in pregnancy-associated cardiomyopathy and the 2018 Heart Failure Society of America/American College of Medical Genomics guideline for the genetic evaluation of cardiomyopathy. She is currently a PhD Candidate in the Translational Health Sciences at George Washington University, where she applies knowledge translation and implementation science principles to address the underutilization of cardiovascular genetic testing.
Andrew Landstrom, MD, PhD
Andrew Landstrom, MD, PhD
Dr. Landstrom is a physician scientist who specializes in the care of children and young adults with arrhythmias, heritable cardiovascular diseases, and sudden unexplained death syndromes. As a clinician, he is trained in pediatric cardiology with a focus on arrhythmias and genetic diseases of the heart. He specializes in caring for patients with heritable arrhythmia (channelopathies) such as long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome. He also specializes in the evaluation of children following a cardiac arrest or after the sudden and unexplained death of a family member. He has expertise in cardiovascular genetics and uses it to identify individuals in a family who may be at risk of a disease, even if all clinical testing is negative.
Quan Bui, MD
Quan Bui, MDDr. Quan Bui is an Assistant Professor of Medicine at the University of California San Diego. He is an academic cardiologist with expertise in advanced heart failure and transplant cardiology whose research and clinical interests are focused on the study and treatment of patients with genetic cardiomyopathy. Dr. Bui has established himself as an expert in Danon Disease, a rare X-linked disorder that leads to end stage cardiomyopathy, through completion of multiple deep clinical phenotyping studies and involvement with associated gene therapy clinical trial. His current research focuses on the pragmatic implementation of genomic applications into cardiovascular clinical practice. Specifically, Dr. Bui has been awarded a prestigious American Heart Association Career Development grant to improve implementation of genetic testing in cardiomyopathy patients. Dr. Bui hopes to advance personalized cardiovascular medicine, ultimately improving patient outcomes and transforming the standard of care in heart failure.